It took me two-and-a-half years, but I finally figured out that the Fox medical drama House has patterned the title character, an arrogant doctor who solves sadistic medical mysteries, after Sherlock Holmes.
Beyond the similarity of the names Holmes and House, both feature characters who are arrogant and addicted to drugs (Holmes abuses cocaine and morphine; House takes Vicodin for a leg ailment). They're both incredibly difficult to get along with and have only close friend and confidante -- Holmes has Dr. Watson, House has Dr. Wilson.
In an overt nod to Holmes on this week's episode, House was shopping for a cane when he put a curled Baskerville pipe in his mouth. (You'd think a guy whose patients regularly develop excruciating maladies from exposure to exotic toxins would have the sense not to do that.)
My favorite connection is that both characters love lowbrow culture. Holmes is a regular reader of "agony columns," melodramatic Dear Abby-style advice features for the lovelorn and desperate, and House is a regular viewer of General Hospital who once used the pseudonym Luke N. Laura.